TargetMol

Gigantol

Product Code:
 
TAR-TL0008
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TL0008-1mg1mg£132.00
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TAR-TL0008-1mL1 mL * 10 mM (in DMSO)£205.00
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TAR-TL0008-5mg5mg£216.00
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TAR-TL0008-10mg10mg£289.00
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TAR-TL0008-25mg25mg£422.00
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TAR-TL0008-50mg50mg£551.00
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TAR-TL0008-100mg100mg£756.00
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Further Information

Bioactivity:
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity.
CAS:
67884-30-4
Formula:
C16H18O4
Molecular Weight:
274.316
Pathway:
Cytoskeletal Signaling; Metabolism; Stem Cells
Purity:
0.9873
SMILES:
COc1cc(O)cc(CCc2ccc(OC)c(O)c2)c1
Target:
Wnt/beta-catenin; Glucosidase

References

Yu S, et al. Gigantol inhibits Wnt/?-catenin signaling and exhibits anticancer activity in breast cancer cells:[J]. Bmc Complementary & Alternative Medicine, 2018, 18(1):59. Chen H, et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-?B signaling pathway[J]. Oncology Reports, 2017, 37(2):865. Wu J, et al. Gigantol from Dendrobium chrysotoxum, Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro, mechanistic study[J]. Journal of Ethnopharmacology, 2017, 198:255-261. Chen H, et al. Protective effect of gigantol against hydrogen peroxide?induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.[J]. Molecular Medicine Reports, 2018, 17(2):3267-3273.