TargetMol

Ganoderic acid DM

Product Code:
 
TAR-TN1663
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1663-5mg5mg£304.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TN1663-1mL1 mL * 10 mM (in DMSO)£673.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.
CAS:
173075-45-1
Formula:
C30H44O4
Molecular Weight:
468.678
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H][C@@]12CC(=O)C3=C(CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCC=C(/C)C(O)=O)[C@@]1(C)CCC(=O)C2(C)C
Target:
PARP; Androgen Receptor; CDK

References

Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.Fitoterapia. 2012 Mar;83(2):408-14.