TargetMol

Ecdysone

Product Code:
 
TAR-TN3910
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN3910-5mg5mg£371.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TN3910-1mL1 mL * 10 mM (in DMSO)£414.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
CAS:
3604-87-3
Formula:
C27H44O6
Molecular Weight:
464.63
Pathway:
Metabolism; Autophagy; Apoptosis; Endocrinology/Hormones; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
C[C@H]([C@H](O)CCC(C)(C)O)C1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)C3CC[C@]12C
Target:
Apoptosis; ATPase; Glucocorticoid Receptor; Potassium Channel; Sodium Channel; Endogenous Metabolite; Autophagy

References

Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3? Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225. Gautam NK, Verma P, Tapadia MG. Ecdysone regulates morphogenesis and function of Malpighian tubules in Drosophila melanogaster through EcR-B2 isoform. Dev Biol. 2015 Feb 15;398(2):163-76. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645. Nishita Y. Ecdysone response elements in the distal promoter of the Bombyx Broad-Complex gene, BmBR-C. Insect Mol Biol. 2014 Jun;23(3):341-56.