TargetMol

Physalin H

Product Code:
 
TAR-TN4778
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-TN4778-5mg5mg£409.00
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This product comes from: United States.
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Further Information

Bioactivity:
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74?0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.
CAS:
70241-09-7
Formula:
C28H31ClO10
Molecular Weight:
562.99
Pathway:
Microbiology/Virology; Autophagy; Immunology/Inflammation
Purity:
0.98
SMILES:
C[C@@]12OC(=O)[C@]3(O)CC[C@H]4[C@@H](C[C@@H](O)[C@@]5(Cl)CC=CC(=O)[C@]45C)[C@]45O[C@@]13[C@H](C4=O)[C@]1(C)C[C@H]2OC(=O)[C@@H]1CO5
Target:
gp12/CD4; Antifection; Autophagy