TargetMol

Macluraxanthone

Product Code:
 
TAR-TN5912
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-TN5912-5mg5mg£1,347.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TN5912-1mL1 mL * 10 mM (in DMSO)£1,595.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Macluraxanthone has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide.
CAS:
5848-14-6
Formula:
C23H22O6
Molecular Weight:
0
Pathway:
Apoptosis|oxidation-reduction
Purity:
0.98
SMILES:
CC(C)(C=C)c1c2OC(C)(C)C=Cc2c(O)c2c1oc1c(O)c(O)ccc1c2=O
Target:
TNF|Antioxidant

References

Siripong P, et al. Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots. Asian Pac J Cancer Prev. 2012;13(7):3519-3528. Ng IMJ, et al. Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function. Nat Prod Res. 2021;35(23):5409-5414. Khan MT, et al. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chem Biol Interact. 2009;181(3):383-389. Xiang Q, et al. Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury. Front Pharmacol. 2020;11:452. Loisel S, et al. Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia. J Hematol Oncol. 2010;3:49.