TargetMol

Conantokin G

Product Code:
 
TAR-TP2060
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2060-5mg5mg£573.00
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Further Information

Bioactivity:
GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.
CAS:
93438-65-4
Formula:
C88H138N26O44
Molecular Weight:
2264.21
Purity:
0.98
SMILES:
0

References

Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614 PMID: Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID: Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp.Ther. 294 378 PMID: