TargetMol

Z-WEHD-FMK

Product Code:
 
TAR-TP2161
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2161-100mg100mgEnquire
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TAR-TP2161-200mg200mgEnquire
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TAR-TP2161-5mg5mg£370.00
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TAR-TP2161-10mg10mg£503.00
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TAR-TP2161-50mg50mg£1,364.00
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This product comes from: United States.
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Further Information

Bioactivity:
Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
CAS:
210345-00-9
Formula:
C37H42FN7O10
Molecular Weight:
763.77
Pathway:
Apoptosis; Proteases/Proteasome
Purity:
0.98
SMILES:
0
Target:
Caspase

References

Newman ZL, et al. CA-074Me protection against anthrax lethal toxin.Infect Immun. 2009 Oct;77(10):4327-36. Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052. Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1? release in murine bone marrow-derived macrophages.PLoS One.?2018 Aug 23;13(8):e0199936. Kamada S, et al. Caspase-4?and?caspase-5,?members?of the?ICE/CED-3?family?of?cysteine?proteases, are?CrmA-inhibitable?proteases.Cell Death Differ.?1997 Aug;4(6):473-8.