TargetMol

Amifostine thiol dihydrochloride

Product Code:
 
TAR-TQ0133
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0133-5mg5mg£108.00
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TAR-TQ0133-1mL1 mL * 10 mM (in DMSO)£122.00
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TAR-TQ0133-10mg10mg£130.00
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TAR-TQ0133-25mg25mg£169.00
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Quantity:
TAR-TQ0133-50mg50mg£217.00
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This product comes from: United States.
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Further Information

Bioactivity:
WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.
CAS:
14653-77-1
Formula:
C5H16Cl2N2S
Molecular Weight:
207.16
Pathway:
Apoptosis
Purity:
0.95
SMILES:
SCCNCCCN.Cl.Cl
Target:
p53

References

Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun;297(3):1067-73. Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496. Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.