TargetMol

K145 hydrochloride

Product Code:
 
TAR-TQ0138
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0138-5mg5mg£111.00
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TAR-TQ0138-10mg10mg£125.00
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TAR-TQ0138-25mg25mg£148.00
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TAR-TQ0138-50mg50mg£179.00
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This product comes from: United States.
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Further Information

Bioactivity:
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 ?M and Ki of 6.4 ?M. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
CAS:
1449240-68-9
Formula:
C18H25ClN2O3S
Molecular Weight:
384.92
Pathway:
GPCR/G Protein; Apoptosis
Purity:
0.98
SMILES:
Cl.CCCCOc1ccc(CCC=C2/SC(=O)N(CCN)C2=O)cc1
Target:
Apoptosis; S1P Receptor

References

Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.