TargetMol

Lapatinib

Product Code:
 
TAR-T0078
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0078-1mL1 mL * 10 mM (in DMSO)£95.00
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TAR-T0078-25mg25mg£102.00
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TAR-T0078-50mg50mg£111.00
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TAR-T0078-100mg100mg£124.00
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TAR-T0078-200mg200mg£138.00
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TAR-T0078-500mg500mg£174.00
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TAR-T0078-1g1g£189.00
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Further Information

Bioactivity:
Lapatinib is a dual inhibitor of Lapatinib is a dual ErbB2/EGFR (IC50: 9.2/10.8 nM) inhibitor
CAS:
231277-92-2
Formula:
C29H26ClFN4O4S
Molecular Weight:
581.06
Pathway:
JAK/STAT signaling; Autophagy; Cell Cycle/Checkpoint; Angiogenesis; Tyrosine Kinase/Adaptors; Apoptosis
Purity:
0.9989
SMILES:
CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
Target:
EGFR; Ferroptosis; Autophagy

References

1. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94 2. Chefrour M et al. Positive interaction between lapatinib and capecitabine in human breast cancer models: study of molecular determinants. Fundam Clin Pharmacol. 2012 Aug;26(4):530-7. 3. Wainberg ZA, et al. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin Cancer Res. 2010 Mar 1;16(5):1509-19. 4. Eryilmaz U, et al. S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. PLoS One. 2015 Dec 18;10(12):e0145418.