TargetMol

Zileuton

Product Code:
 
TAR-T0477
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0477-10mg10mg£108.00
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TAR-T0477-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0477-25mg25mg£128.00
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TAR-T0477-50mg50mg£148.00
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TAR-T0477-100mg100mg£219.00
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TAR-T0477-200mg200mg£294.00
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Quantity:
TAR-T0477-500mg500mg£447.00
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Further Information

Bioactivity:
Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.
CAS:
111406-87-2
Formula:
C11H12N2O2S
Molecular Weight:
236.29
Pathway:
Neuroscience; Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism
Purity:
0.9956
SMILES:
CC(N(O)C(N)=O)c1cc2ccccc2s1
Target:
Ferroptosis; Lipoxygenase; COX

References

1. Rossi A1, et al. Br J Pharmacol, 2010, 161(3), 555-570. 2. Bertr?n X, et al.Gut. 1996 Jun;38(6):899-904. 3. Genovese T, et al. Br J Pharmacol, 2008, 153(3), 568-582. 4. Patel NS, et al. Mol Pharmacol, 2004, 66(2), 220-227. 5. Rao NL, et al. J Pharmacol Exp Ther, 2007, 321(3), 1154-1160. 6. Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10(3):e0121402 7. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10 8. Liu L, Zhang P, Zhang Z, et al. 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats[J]. Aging (Albany NY). 2021, 13(8): 11752.