TargetMol

AHR antagonist 5

Product Code:
 
TAR-T10272
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10272-5mg5mg£511.00
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Quantity:
TAR-T10272-50mg50mg£1,661.00
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Quantity:
TAR-T10272-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397 (example 39; IC50 < 0.5 μμ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.
CAS:
2247953-39-3
Formula:
C25H27Cl3FN7
Molecular Weight:
550.89
Purity:
0.98
SMILES:
Cl.Cl.Cl.CC(C)c1cnn2c(N[C@@H]3CCc4[nH]c5ccccc5c4C3)nc(nc12)-c1cncc(F)c1

References

1. Alfredo C. Castro, et al. Indole ahr inhibitors and uses thereof. WO2018195397A2.