TargetMol

Ceranib-2

Product Code:
 
TAR-T10761
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10761-5mg5mg£108.00
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TAR-T10761-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T10761-10mg10mg£142.00
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TAR-T10761-25mg25mg£222.00
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TAR-T10761-50mg50mg£322.00
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TAR-T10761-100mg100mg£483.00
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Further Information

Bioactivity:
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
CAS:
1402830-75-4
Formula:
C25H19NO3
Molecular Weight:
381.431
Pathway:
Apoptosis; GPCR/G Protein
Purity:
0.98
SMILES:
COc1ccc(C=CC(=O)c2c(-c3ccccc3)c3ccccc3[nH]c2=O)cc1
Target:
Apoptosis; S1P Receptor

References

1. Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10(11):2052-61. 2. Kus G, et al. Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2. In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1056-63.