TargetMol

VX-984

Product Code:
 
TAR-T11067
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T11067-1mg1mg£213.00
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TAR-T11067-5mg5mg£436.00
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TAR-T11067-1mL1 mL * 10 mM (in DMSO)£464.00
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TAR-T11067-10mg10mg£610.00
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TAR-T11067-25mg25mg£922.00
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TAR-T11067-50mg50mg£1,219.00
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Quantity:
TAR-T11067-100mg100mg£1,613.00
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Quantity:
TAR-T11067-500mg500mg£3,163.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
VX-984 is a potent DNA-PK inhibitor.
CAS:
1476074-39-1
Formula:
C23H23N7O
Molecular Weight:
415.497
Pathway:
PI3K/Akt/mTOR signaling|DNA Damage/DNA Repair
Purity:
0.98
SMILES:
[2H]c1nc(C)nc([2H])c1-c1cc(NC[C@@H](C)c2cccc3c(ccnc23)C(=O)NC)ncn1
Target:
DNA-PK

References

Cindy R Timme , et al. The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts. Mol Cancer Ther. 2018 Jun;17(6):1207-1216. Atif J Khan, et al. VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells. Oncotarget. 2018 May 25;9(40):25833-25841.