TargetMol

iFSP1

Product Code:
 
TAR-T11631
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11631-10mg10mg£107.00
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TAR-T11631-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T11631-50mg50mg£211.00
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TAR-T11631-100mg100mg£334.00
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This product comes from: United States.
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Further Information

Bioactivity:
iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3.iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1.
CAS:
150651-39-1
Formula:
C20H13N5
Molecular Weight:
323.359
Pathway:
Cell Cycle/Checkpoint; Apoptosis
Purity:
0.9974
SMILES:
Cc1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N
Target:
Ferroptosis

References

1. Doll S, et al. FSP1?is a?glutathione-independent?ferroptosis?suppressor.Nature.?2019 Nov;575(7784):693-698.