TargetMol

IRAK inhibitor 4

Product Code:
 
TAR-T11672
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11672-5mg5mg£607.00
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Quantity:
TAR-T11672-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T11672-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 inhibitor.
CAS:
1012104-68-5
Formula:
C33H35F3N6O3
Molecular Weight:
620.677
Purity:
0.98
SMILES:
CC(C)CCNC(=O)c1ccc2n(C3CCC(O)CC3)c(Nc3n[nH]c4ccc(cc34)-c3ccccc3OC(F)(F)F)nc2c1

References

1. Marinho FV, et al. Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection. J Immunol. 2016 Sep 1;197(5):1852-63. 2. Talreja J, et al. Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1? and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells. J Immunol. 2016 Aug 15;197(4):1368-78. 3. Li Z, et al. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest. 2015 Mar 2;125(3):1081-97.