TargetMol

M2698

Product Code:
 
TAR-T11928
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11928-1mg1mg£128.00
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TAR-T11928-5mg5mg£213.00
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TAR-T11928-1mL1 mL * 10 mM (in DMSO)£238.00
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TAR-T11928-10mg10mg£303.00
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TAR-T11928-25mg25mg£535.00
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TAR-T11928-50mg50mg£740.00
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Quantity:
TAR-T11928-100mg100mg£994.00
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Further Information

Bioactivity:
M2698 can cross the blood-brain barrier and has anti-cancer activity. M2698 is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3.
CAS:
1379545-95-5
Formula:
C21H19ClF3N5O
Molecular Weight:
449.86
Pathway:
Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Target:
Akt

References

1. Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6(4):806-18.