TargetMol

Amsacrine

Product Code:
 
TAR-T1206
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T1206-50mg50mgEnquire
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TAR-T1206-1mL1 mL * 10 mM (in DMSO)£94.00
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TAR-T1206-10mg10mg£102.00
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TAR-T1206-25mg25mg£117.00
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Further Information

Bioactivity:
Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II.
CAS:
51264-14-3
Formula:
C21H19N3O3S
Molecular Weight:
393.46
Pathway:
Autophagy; Membrane transporter/Ion channel; DNA Damage/DNA Repair
Purity:
0.98
SMILES:
COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
Target:
Potassium Channel; Topoisomerase; Autophagy

References

1. Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94. 2. Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33. 3. Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68(7-8):1989-97. 4. Lee YC, et al. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2016 Oct 19. 5. Fu, Wan, et al. A novel acridine derivative,. LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells [J]. Cell death & disease. 2017 Oct 5;8(10):e3086.