TargetMol

NXT629

Product Code:
 
TAR-T12278
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12278-5mg5mg£502.00
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TAR-T12278-50mg50mg£1,821.00
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TAR-T12278-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
CAS:
1454925-59-7
Formula:
C35H39N5O3S
Molecular Weight:
609.79
Pathway:
Endocrinology/Hormones
Purity:
0.98
SMILES:
CCn1c(CCCc2ccc(cc2)-c2ccc(NS(=O)(=O)c3ccccc3)cn2)nn(Cc2ccc(cc2)C(C)(C)C)c1=O
Target:
Estrogen/progestogen Receptor

References

1. Bravo Y, et al. Identification of the first potent, selective and bioavailable PPAR? antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. 2. Stebbins KJ, et al. In vitro and in vivo pharmacology of NXT629, a novel and selective PPAR? antagonist. Eur J Pharmacol. 2017 Aug 15;809:130-140.