TargetMol

ORM-10962

Product Code:
 
TAR-T12322
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12322-5mg5mg£470.00
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TAR-T12322-50mg50mg£1,661.00
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Quantity:
TAR-T12322-100mg100mg£2,079.00
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Further Information

Bioactivity:
ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55 nM , respectively).
CAS:
763926-98-3
Formula:
C27H29N3O4
Molecular Weight:
459.546
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.98
SMILES:
OC1CCN(CC(=O)Nc2ccc(Oc3ccc4OC(CCc4c3)c3ccccc3)nc2)CC1
Target:
Calcium Channel

References

1. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041. 2. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.