TargetMol

PAT-1251

Product Code:
 
TAR-T12371L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12371L-1mg1mg£229.00
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TAR-T12371L-5mg5mg£470.00
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TAR-T12371L-1mL1 mL * 10 mM (in DMSO)£510.00
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TAR-T12371L-10mg10mg£651.00
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TAR-T12371L-25mg25mg£978.00
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TAR-T12371L-50mg50mg£1,291.00
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TAR-T12371L-100mg100mg£1,661.00
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TAR-T12371L-500mg500mg£3,259.00
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Further Information

Bioactivity:
PAT-1251 is a potent, selective, and oral lysyl oxidase-like 2 inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively. PAT-1251 is used in the research of fibrotic diseases. It also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively).
CAS:
2007885-39-2
Formula:
C18H17F4N3O3
Molecular Weight:
399.346
Pathway:
Neuroscience
Purity:
0.98
SMILES:
NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F
Target:
Monoamine Oxidase

References

1. Rowbottom MW, et al. Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem. 2017 May 25;60(10):4403-4423.