TargetMol

SB-657510

Product Code:
 
TAR-T12848
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12848-1mg1mg£172.00
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Quantity:
TAR-T12848-5mg5mg£374.00
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Quantity:
TAR-T12848-1mL1 mL * 10 mM (in DMSO)£410.00
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TAR-T12848-10mg10mg£527.00
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TAR-T12848-25mg25mg£804.00
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Quantity:
TAR-T12848-50mg50mg£1,058.00
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Quantity:
TAR-T12848-100mg100mg£1,420.00
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Quantity:
TAR-T12848-500mg500mg£2,769.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SB-657510 is a selective antagonist of urotensin II (UII) receptor (UT).
CAS:
474960-44-6
Formula:
C19H22BrClN2O5S
Molecular Weight:
505.81
Pathway:
GPCR/G Protein|Others
Purity:
0.98
SMILES:
COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Target:
Others|Neurotensin Receptor

References

1. Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013 Jul 30;21(4):277-83. 2. Behm DJ, et al. Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br J Pharmacol. 2008 Oct;155(3):374-86. 3. Watson AM, et al. Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia. 2013 May;56(5):1155-65.