TargetMol

TC-MCH 7c

Product Code:
 
TAR-T13101
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13101-1mg1mg£198.00
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Quantity:
TAR-T13101-1mL1 mL * 10 mM (in DMSO)£420.00
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TAR-T13101-5mg5mg£458.00
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TAR-T13101-10mg10mg£627.00
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TAR-T13101-25mg25mg£922.00
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Quantity:
TAR-T13101-50mg50mg£1,219.00
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Quantity:
TAR-T13101-100mg100mg£1,613.00
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Quantity:
TAR-T13101-500mg500mg£3,171.00
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Further Information

Bioactivity:
TC-MCH 7c is an orally available, selective and brain-penetrable antagonist of MCH1R(IC50 of 5.6 nM for hMCH1R),and is a phenylpyridone derivative.
CAS:
864756-35-4
Formula:
C24H25FN2O3
Molecular Weight:
408.473
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
Fc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
Target:
Melanin-concentrating Hormone Receptor (MCHR)

References

1. Ito M, et al. Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur J Pharmacol. 2009 Dec 10;624(1-3):77-83. 2. Haga Y, et al. Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg Med Chem. 2011 Jan 15;19(2):883-93.