TargetMol

TMP780

Product Code:
 
TAR-T13172
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13172-5mg5mg£371.00
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TAR-T13172-50mg50mg£1,765.00
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TAR-T13172-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
CAS:
1422053-03-9
Formula:
C31H30N2O4
Molecular Weight:
494.591
Pathway:
Metabolism
Purity:
0.98
SMILES:
Cc1noc(C)c1[C@@H](O)c1cc2cc(CC(=O)N[C@@H](c3ccccc3)c3ccc(C)cc3C)ccc2o1
Target:
ROR

References

1. Skepner J, et al. Pharmacologic inhibition of ROR?t regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75.