TargetMol

3-Oxo-5β-cholanoic acid

Product Code:
 
TAR-T13502
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13502-10mg10mg£103.00
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TAR-T13502-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T13502-25mg25mg£121.00
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TAR-T13502-50mg50mg£144.00
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Further Information

Bioactivity:
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM).
CAS:
1553-56-6
Formula:
C24H38O3
Molecular Weight:
374.565
Pathway:
Metabolism
Purity:
0.98
SMILES:
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Target:
ROR

References

1. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.