TargetMol

A-3 hydrochloride

Product Code:
 
TAR-T14069
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14069-5mg5mg£119.00
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TAR-T14069-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T14069-10mg10mg£148.00
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TAR-T14069-25mg25mg£209.00
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TAR-T14069-50mg50mg£303.00
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TAR-T14069-100mg100mg£442.00
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Quantity:
TAR-T14069-500mg500mg£863.00
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Further Information

Bioactivity:
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
CAS:
78957-85-4
Formula:
C12H14Cl2N2O2S
Molecular Weight:
321.22
Pathway:
Neuroscience; Stem Cells; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; Chromatin/Epigenetic; Metabolism
Purity:
0.9979
SMILES:
Cl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Target:
CaMK; Casein Kinase; PKA; PKC

References

1. Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol.?1986 Jun;29(6):577-81.