TargetMol

BMS CCR2 22

Product Code:
 
TAR-T14688
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14688-1mg1mg£148.00
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TAR-T14688-5mg5mg£309.00
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TAR-T14688-1mL1 mL * 10 mM (in DMSO)£382.00
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TAR-T14688-10mg10mg£426.00
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TAR-T14688-25mg25mg£647.00
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TAR-T14688-50mg50mg£863.00
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TAR-T14688-100mg100mg£1,139.00
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TAR-T14688-500mg500mg£2,215.00
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Further Information

Bioactivity:
BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM)[1][2].
CAS:
445479-97-0
Formula:
C28H34F3N5O4S
Molecular Weight:
593.67
Pathway:
Microbiology/Virology; Immunology/Inflammation
Purity:
0.98
SMILES:
CSc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC(C)C)C(F)(F)F
Target:
CCR

References

1. Cherney RJ, et al. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J Med Chem. 2008 Feb 28;51(4):721-4. 2. Kredel S, et al. High-content analysis of CCR2 antagonists on human primary monocytes. J Biomol Screen. 2011 Aug;16(7):683-93. 3. D'Antoni ML, et al. Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression. J Leukoc Biol. 2018 Dec;104(6):1241-1252.