TargetMol

Karenitecin

Product Code:
 
TAR-T14703
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14703-5mg5mg£410.00
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Quantity:
TAR-T14703-50mg50mg£1,669.00
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Quantity:
TAR-T14703-100mg100mg£2,568.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
CAS:
203923-89-1
Formula:
C25H28N2O4Si
Molecular Weight:
448.594
Pathway:
DNA Damage/DNA Repair
Purity:
0.98
SMILES:
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4c(CC[Si](C)(C)C)c3Cn1c2=O
Target:
Topoisomerase

References

1. Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol. 2000 Mar;57(3):453-9. 2. Van Hattum AH, et al. New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer. Int J Cancer. 2000 Oct 15;88(2):260-6.