TargetMol

Dapansutrile

Product Code:
 
TAR-T15052
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15052-5mg5mg£103.00
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TAR-T15052-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T15052-10mg10mg£124.00
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TAR-T15052-25mg25mg£177.00
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TAR-T15052-50mg50mg£257.00
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TAR-T15052-100mg100mg£371.00
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TAR-T15052-200mg200mg£486.00
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TAR-T15052-500mg500mg£650.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
CAS:
54863-37-5
Formula:
C4H7NO2S
Molecular Weight:
133.17
Pathway:
NF-κb; Immunology/Inflammation
Purity:
0.98
SMILES:
CS(=O)(=O)CCC#N
Target:
NOD-like Receptor (NLR); NOD

References

1. Alba S?nchez-Fern?ndez, Skouras D B , Dinarello C A , et al. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis[J]. Frontiers in Immunology, 2019, 10. 2. Toldo S, et al. The NLRP3 Inflammasome Inhibitor, Dapansutrile, Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.