TargetMol

GNE-049

Product Code:
 
TAR-T15397
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15397-5mg5mg£438.00
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TAR-T15397-50mg50mg£1,902.00
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Quantity:
TAR-T15397-100mg100mg£2,697.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, respectively).
CAS:
1936421-41-8
Formula:
C27H32F2N6O2
Molecular Weight:
510.59
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Target:
Epigenetic Reader Domain

References

1. Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.