TargetMol

IHVR-19029

Product Code:
 
TAR-T15554
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15554-5mg5mg£370.00
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TAR-T15554-50mg50mg£1,332.00
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Quantity:
TAR-T15554-100mg100mg£1,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Ebola virus, Dengue virus, and Rift Valley fever virus.
CAS:
1447464-73-4
Formula:
C23H45N3O5
Molecular Weight:
443.629
Purity:
0.98
SMILES:
CC(C)(C)NC(=O)N(CCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C1CCCCC1

References

1. Bray M, et al. Meeting report: 31st International Conference on Antiviral Research. Antiviral Res. 2018 Oct;158:88-102. 2. Jin hong Chang, et al. Small molecule inhibitors of ER ?-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Research. Volume 98, Issue 3, June 2013, Pages 432-440. 3. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.ACS Med Chem Lett. 2017 Jan 17;8(2):157-162. 4. Ma J, et al. Enhancing the antiviral potency of ER ?-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo. Antiviral Res. 2018 Feb;150:112-122.