TargetMol

Namitecan

Product Code:
 
TAR-T16268
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16268-5mg5mg£404.00
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Quantity:
TAR-T16268-50mg50mg£1,765.00
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Quantity:
TAR-T16268-100mg100mg£2,785.00
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This product comes from: United States.
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Further Information

Bioactivity:
Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
CAS:
372105-27-6
Formula:
C23H22N4O5
Molecular Weight:
434.452
Purity:
0.98
SMILES:
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4c(C=NOCCN)c3Cn1c2=O

References

1. De Cesare M, et al. Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number. Clin Cancer Res. 2014 Feb 15;20(4):995-1006. 2. Zuco V, et al. Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma. Biochem Pharmacol. 2010 Feb 15;79(4):535-41.