TargetMol

Paroxetine hydrochloride

Product Code:
 
TAR-T1636
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1636-10mg10mg£95.00
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TAR-T1636-25mg25mg£109.00
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TAR-T1636-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1636-50mg50mg£114.00
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TAR-T1636-100mg100mg£133.00
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TAR-T1636-200mg200mg£160.00
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TAR-T1636-500mg500mg£193.00
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This product comes from: United States.
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Further Information

Bioactivity:
Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
CAS:
78246-49-8
Formula:
C19H21ClFNO3
Molecular Weight:
365.83
Pathway:
Neuroscience; Autophagy; GPCR/G Protein
Purity:
0.9991
SMILES:
Cl.Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
Target:
5-HT Receptor; Serotonin Transporter; GRK; AChR; Autophagy

References

1. Le Poul E, et al. Naunyn Schmiedebergs Arch Pharmacol, 1995, 352(2), 141-148. 2. von Moltke LL, et al. J Clin Psychopharmacol, 1995, 15(2), 125-131. 3. Thomas DR, et al. Psychopharmacology (Berl), 1987, 93(2), 193-200. 4. Bertelsen KM, et al. Drug Metab Dispos, 2003, 31(3), 289-293. 6. Lassen TR, et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112(3):26. 7. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069. 8. Wang K, Gong Q, Zhan Y, et al. Blockage of autophagic flux and induction of mitochondria fragmentation by Paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway[J]. Frontiers in Cell and Developmental Biology. 2020, 7: 397.