TargetMol

Pimonidazole hydrochloride

Product Code:
 
TAR-T16536
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16536-10mg10mg£103.00
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TAR-T16536-25mg25mg£141.00
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TAR-T16536-50mg50mg£204.00
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TAR-T16536-100mg100mg£301.00
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This product comes from: United States.
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Further Information

Bioactivity:
Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
CAS:
70132-51-3
Formula:
C11H19ClN4O3
Molecular Weight:
290.75
Purity:
1
SMILES:
Cl.OC(CN1CCCCC1)Cn1ccnc1[N+]([O-])=O

References

1. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7. 2. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639. 3. Aguilera KY, Brekken RA. Hypoxia Studies with Pimonidazole in vivo. Bio Protoc. 2014 Oct 5;4(19):e1254. 4. Chang WL, Chang YC, Lin KT, Li HR, Pai CY, Chen JH, Su YH. Asymmetric distribution of hypoxia-inducible factor ? regulates dorsoventral axis establishment in the early sea urchin embryo. Development. 2017 Aug 15;144(16):2940-2950. 5. Evans SM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A. Molecular probes for imaging of hypoxia in the retina. Bioconjug Chem. 2014 Nov 19;25(11):2030-7.