TargetMol

Poloxin

Product Code:
 
TAR-T16560
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16560-10mg10mg£109.00
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TAR-T16560-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T16560-25mg25mg£163.00
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TAR-T16560-50mg50mg£236.00
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TAR-T16560-100mg100mg£316.00
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TAR-T16560-200mg200mg£437.00
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Further Information

Bioactivity:
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
CAS:
321688-88-4
Formula:
C18H19NO3
Molecular Weight:
297.354
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9919
SMILES:
CC(C)C1=CC(=NOC(=O)c2ccccc2C)C(C)=CC1=O
Target:
PLK

References

1. Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol. 2011 Oct;179(4):2091-9. 2. Sanhaji M, et al. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. Cell Cycle. 2012 Feb 1;11(3):543-53. 3. Lee KS, et al. Pinning down the polo-box domain. Chem Biol. 2008 May;15(5):415-6. 4. Reindl W, et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol. 2008 May;15(5):459-66.