TargetMol

GNF-5

Product Code:
 
TAR-T1803
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1803-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1803-10mg10mg£111.00
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TAR-T1803-25mg25mg£133.00
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TAR-T1803-50mg50mg£179.00
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TAR-T1803-100mg100mg£230.00
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TAR-T1803-200mg200mg£359.00
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Further Information

Bioactivity:
GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22?0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.
CAS:
778277-15-9
Formula:
C20H17F3N4O3
Molecular Weight:
418.376
Pathway:
Microbiology/Virology; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9998
SMILES:
OCCNC(=O)c1cccc(c1)-c1cc(Nc2ccc(OC(F)(F)F)cc2)ncn1
Target:
SARS-CoV; Bcr-Abl

References

1. Zhang J, et al. Nature. 2010, 463(7280), 501-506. 2. Deng X, et al. J Med Chem. 2010, 53(19), 6934-6946.