TargetMol

Benazeprilat

Product Code:
 
TAR-T19722
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19722-1mg1mg£169.00
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TAR-T19722-5mg5mg£306.00
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TAR-T19722-10mg10mg£428.00
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TAR-T19722-25mg25mg£661.00
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TAR-T19722-50mg50mg£863.00
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TAR-T19722-100mg100mg£1,179.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Benazeprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.28 nM in plasma from the dog). Benazeprilat is also the active metabolite of the prodrug benazepril.
CAS:
86541-78-8
Formula:
C22H24N2O5
Molecular Weight:
396.443
Pathway:
Metabolism|Endocrinology/Hormones
Purity:
0.98
SMILES:
OC(=O)CN1c2ccccc2CC[C@H](N[C@@H](CCc2ccccc2)C(O)=O)C1=O
Target:
Endogenous Metabolite|RAAS

References

1. Serrano-Rodr?guez JM, G?mez-D?ez M, Esgueva M, Castej?n-Riber C, Mena-Bravo A, Priego-Capote F, Ayala N, Caballero JM, Mu?oz A. Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses. Res Vet Sci. 2017 Mar 28;114:117-122. doi: 10.1016/j.rvsc.2017.03.016. [Epub ahead of print] PubMed PMID: 28371693. 2. Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned? Rev Physiol Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Review. PubMed PMID: 26428686. 3. Qian M, Chen T, Zhou D, Zhang Z, Zhang Q, Tang S, Xiao X. Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs. J Vet Pharmacol Ther. 2016 Feb;39(1):98-101. doi: 10.1111/jvp.12252. Epub 2015 Jul 30. PubMed PMID: 26228576. 4. Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. doi: 10.1007/s11095-014-1587-9. Epub 2014 Dec 2. PubMed PMID: 25446774.