TargetMol

Afatinib

Product Code:
 
TAR-T21312
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21312-10mg10mg£109.00
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TAR-T21312-50mg50mg£167.00
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TAR-T21312-100mg100mg£191.00
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TAR-T21312-200mg200mg£222.00
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Further Information

Bioactivity:
Afatinib is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).
CAS:
850140-72-6
Formula:
C24H25ClFN5O3
Molecular Weight:
485.94
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis; Autophagy
Purity:
0.999
SMILES:
CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1
Target:
EGFR; Autophagy

References

1. Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99. 2. Wang XK, et al. Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget. 2014 Dec 15;5(23):11971-85.