TargetMol

Tacrolimus

Product Code:
 
TAR-T2144
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2144-10mg10mg£103.00
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TAR-T2144-25mg25mg£117.00
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TAR-T2144-50mg50mg£125.00
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TAR-T2144-100mg100mg£156.00
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TAR-T2144-200mg200mg£191.00
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TAR-T2144-500mg500mg£276.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tacrolimus can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
CAS:
104987-11-3
Formula:
C44H69NO12
Molecular Weight:
804.02
Pathway:
Microbiology/Virology; Autophagy; Metabolism; ; PI3K/Akt/mTOR signaling
Purity:
0.9994
SMILES:
CO[C@@H]1C[C@@H](CC[C@H]1O)C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)CC(C)=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC
Target:
Phosphatase; Antibacterial; Antibiotic; mTOR; Autophagy

References

1. Dumont FJ. FK506, an immunosuppressant targeting calcineurin function. Curr Med Chem. 2000 Jul;7(7):731-48. 2. Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF?1? expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92. 3. Fruman DA, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3686-90. 4. Muthuraman A, Sood S. Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats. J Brachial Plex Peripher Nerve Inj. 2010 Jun 7;5:13. 6. Yuwei He, et al. Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis. Nano Res. 30 June 2018. 7. Wang W, Ren S, Lu Y, et al. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production. The EMBO Journal. 2021: e106771.