TargetMol

Puromycin dihydrochloride

Product Code:
 
TAR-T2219
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2219-10mg10mg£103.00
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TAR-T2219-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T2219-25mg25mg£130.00
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TAR-T2219-50mg50mg£170.00
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TAR-T2219-100mg100mg£229.00
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This product comes from: United States.
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Further Information

Bioactivity:
Puromycin hydrochloride is a cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.
CAS:
58-58-2
Formula:
C22H31Cl2N7O5
Molecular Weight:
544.43
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Microbiology/Virology
Purity:
0.9986
SMILES:
Cl.Cl.COc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)n2cnc3c(ncnc23)N(C)C)cc1
Target:
ribosome; DNA/RNA Synthesis; Antibacterial; Antibiotic

References

1. Darken MA. Pharmacol Rev. 1964, 16, 223-243. 2. Watanabe S, et al. Biol Reprod. 2005, 72(2), 309-315. 3. Han W, Cao F, Gao X J, et al. ZIC1 acts a tumor suppressor in breast cancer by targeting survivin[J]. International journal of oncology . 2018 Sep;53(3):937-948. 4. Han W, Zhang C, Shi C, et al. Roles of eIF3m in the tumorigenesis of triple negative breast cancer[J]. Cancer Cell International. 2020, 20(1): 1-16. 5. Gao C, Wang H, Wang T, et al. Platelet CLEC?2 regulates neuroinflammation and restores blood brain barrier integrity in a mouse model of traumatic brain injury[J]. Journal of Neurochemistry. 2020: e14983.