TargetMol

2-Methylthioadenosine diphosphate trisodium

Product Code:
 
TAR-T23581
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23581-5mg5mg£850.00
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Quantity:
TAR-T23581-50mg50mg£1,661.00
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Quantity:
TAR-T23581-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation.
CAS:
475193-31-8
Formula:
C11H14N5Na3O10P2S
Molecular Weight:
539.23
Purity:
0.98
SMILES:
[Na+].[Na+].[Na+].CSc1nc(N)c2ncn(C3OC(COP([O-])(=O)OP([O-])([O-])=O)C(O)C3O)c2n1

References

1. Gao ZG, Jacobson KA. Distinct Signaling Patterns of Allosteric Antagonism at the P2Y(1) Receptor. Mol Pharmacol. 2017 Nov;92(5):613-626. doi: 10.1124/mol.117.109660. Epub 2017 Sep 1. PubMed PMID: 28864555; PubMed Central PMCID: PMC5635520. 2. Muscella A, Cossa LG, Vetrugno C, Antonaci G, Marsigliante S. Inhibition of ZL55 cell proliferation by ADP via PKC-dependent signalling pathway. J Cell Physiol. 2018 Mar;233(3):2526-2536. doi: 10.1002/jcp.26128. Epub 2017 Sep 4. PubMed PMID: 28777435. 3. Guarracino JF, Cinalli AR, Fern?ndez V, Roquel LI, Losavio AS. P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. Neuroscience. 2016 Jun 21;326:31-44. doi: 10.1016/j.neuroscience.2016.03.066. Epub 2016 Apr 4. PubMed PMID: 27058149. 4. F?rster D, Reiser G. Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors. Neurochem Int. 2016 Mar;94:57-66. doi: 10.1016/j.neuint.2016.02.006. Epub 2016 Feb 17. PubMed PMID: 26898403.