TargetMol

UniPR129

Product Code:
 
TAR-T26310
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26310-5mg5mg£257.00
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TAR-T26310-50mg50mg£1,026.00
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Quantity:
TAR-T26310-100mg100mg£1,597.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
UniPR129 is a competitive Eph-ephrin antagonist agent that acts by blocking in vitro angiogenesis at low micromolar concentrations.
CAS:
1639159-47-9
Formula:
C36H52N2O4
Molecular Weight:
576.822
Purity:
0.98
SMILES:
C[C@H](CCC(=O)N[C@H](CC(O)=O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

References

1. Giorgio C, Incerti M, Corrado M, Rusnati M, Chiodelli P, Russo S, Callegari D, Ferlenghi F, Ballabeni V, Barocelli E, Lodola A, Tognolini M. Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction. Biochem Pharmacol. 2018 Jan;147:21-29. doi: 10.1016/j.bcp.2017.11.002. Epub 2017 Nov 10. PubMed PMID: 29129483. 2. Incerti M, Russo S, Callegari D, Pala D, Giorgio C, Zanotti I, Barocelli E, Vicini P, Vacondio F, Rivara S, Castelli R, Tognolini M, Lodola A. Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. J Med Chem. 2017 Jan 26;60(2):787-796. doi: 10.1021/acs.jmedchem.6b01642. Epub 2017 Jan 5. PubMed PMID: 28005388. 3. Giorgio C, Russo S, Incerti M, Bugatti A, Vacondio F, Barocelli E, Mor M, Pala D, Hassan-Mohamed I, Gioiello A, Rusnati M, Lodola A, Tognolini M. Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis. Biochem Pharmacol. 2016 Jan 1;99:18-30. doi: 10.1016/j.bcp.2015.10.006. Epub 2015 Oct 14. PubMed PMID: 26462575. 4. Callegari D, Pala D, Scalvini L, Tognolini M, Incerti M, Rivara S, Mor M, Lodola A. Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists. Molecules. 2015 Sep 17;20(9):17132-51. doi: 10.3390/molecules200917132. PubMed PMID: 26393553.