TargetMol

4-Hydroxytoremifene

Product Code:
 
TAR-T29437
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29437-10mg10mg£328.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29437-100mg100mg£1,344.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
4-Hydroxytoremifene is a selective estrogen receptor modulator toremifene active metabolite.
CAS:
110503-62-3
Formula:
C26H28ClNO2
Molecular Weight:
421.97
Purity:
0.98
SMILES:
CN(C)CCOc1ccc(cc1)C(=C(CCCl)c1ccccc1)c1ccc(O)cc1

References

1. Edavana VK, Dhakal IB, Yu X, Williams S, Kadlubar S. Sulfation of 4-hydroxy toremifene: individual variability, isoform specificity, and contribution to toremifene pharmacogenomics. Drug Metab Dispos. 2012 Jun;40(6):1210-5. doi: 10.1124/dmd.111.044040. Epub 2012 Mar 20. PubMed PMID: 22434874; PubMed Central PMCID: PMC3362788. 2. Fan PW, Zhang F, Bolton JL. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides. Chem Res Toxicol. 2000 Jan;13(1):45-52. PubMed PMID: 10649966. 3. Yao D, Zhang F, Yu L, Yang Y, van Breemen RB, Bolton JL. Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones. Chem Res Toxicol. 2001 Dec;14(12):1643-53. PubMed PMID: 11743747. 4. Kangas L. Biochemical and pharmacological effects of toremifene metabolites. Cancer Chemother Pharmacol. 1990;27(1):8-12. PubMed PMID: 2147128.