TargetMol

BMS-587101

Product Code:
 
TAR-T30533
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T30533-5mg5mg£404.00
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TAR-T30533-50mg50mg£1,821.00
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Quantity:
TAR-T30533-100mg100mg£2,319.00
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Further Information

Bioactivity:
BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.
CAS:
509083-77-6
Formula:
C26H20Cl2N4O4S
Molecular Weight:
555.43
Purity:
0.98
SMILES:
CN1C(=O)N(C(=O)[C@]12CN(Cc3cc(cs3)C(=O)O)C[C@H]2c4ccc(cc4)C#N)c5cc(Cl)cc(Cl)c5

References

1. Suchard SJ, Stetsko DK, Davis PM, Skala S, Potin D, Launay M, Dhar TG, Barrish JC, Susulic V, Shuster DJ, McIntyre KW, McKinnon M, Salter-Cid L. An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis. J Immunol. 2010 Apr 1;184(7):3917-26. doi: 10.4049/jimmunol.0901095. Epub 2010 Feb 26. PubMed PMID: 20190141. 2. Li W, Josephs JL, Skiles GL, Humphreys WG. Metabolite generation via microbial biotransformations with Actinomycetes: rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]non7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101) and dasatinib. Drug Metab Dispos. 2008 Apr;36(4):721-30. doi: 10.1124/dmd.107.019570. Epub 2008 Jan 28. PubMed PMID: 18227141. 3. Potin D, Launay M, Monatlik F, et al. Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1. J Med Chem. 2006 Nov 30;49(24):6946-9. PubMed PMID: 17125246.