TargetMol

NVS-SM2

Product Code:
 
TAR-T33764
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33764-5mg5mg£457.00
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Quantity:
TAR-T33764-50mg50mg£1,982.00
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Quantity:
TAR-T33764-100mg100mg£2,560.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
NVS-SM2 is an effective small molecule splicing enhancer of SMN2 with oral activity. NVS-SM2 showed increased exon 7 inclusion and upregulated SMN protein expression in SMA fibroblasts and SMN cells δ7 5025 mouse myoblasts.
CAS:
1562333-92-9
Formula:
C23H30N6O
Molecular Weight:
406.534
Purity:
0.98
SMILES:
CN(C1CC(C)(C)NC(C)(C)C1)c1ccc(nn1)-c1ccc(cc1O)-c1cn[nH]c1

References

Calder AN, Androphy EJ, Hodgetts KJ. Small Molecules in Development for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2016 Aug 16. [Epub ahead of print] PubMed PMID: 27490705.