TargetMol

Orellanine

Product Code:
 
TAR-T33817
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33817-1mg1mg£389.00
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TAR-T33817-1mL1 mL * 10 mM (in DMSO)£672.00
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TAR-T33817-5mg5mg£849.00
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TAR-T33817-10mg10mg£1,123.00
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TAR-T33817-25mg25mg£1,621.00
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TAR-T33817-50mg50mg£2,175.00
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Quantity:
TAR-T33817-100mg100mg£2,906.00
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Further Information

Bioactivity:
Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat liver mitochondria.
CAS:
37338-80-0
Formula:
C10H8N2O6
Molecular Weight:
252.182
Purity:
0.98
SMILES:
Oc1cc[n+]([O-])c(c1O)-c1c(O)c(O)cc[n+]1[O-]

References

Anantharam P, et al. Improved Tissue-Based Analytical Test Methods for Orellanine, a Biomarker of Cortinarius Mushroom Intoxication. Toxins (Basel). 2016 May 21;8(5). Richard JM, et al. Orellanine inhibits protein synthesis in Madin-Darby canine kidney cells, in rat liver mitochondria, and in vitro: indication for its activation prior to in vitro inhibition. Toxicology. 1991 Mar 25;67(1):53-62. Buvall L, et al. Orellanine specifically targets renal clear cell carcinoma. Oncotarget. 2017 Jul 25;8(53):91085-91098. Dinis-Oliveira RJ, et al. Human and experimental toxicology of orellanine. Hum Exp Toxicol. 2016 Sep;35(9):1016-29.