TargetMol

(-)-Viriditoxin

Product Code:
 
TAR-T35437
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35437-10mg10mg£1,086.00
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Further Information

Bioactivity:
(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 μg/ml). It inhibits polymerization and the GTPase activity of E. coli FtsZ, a tubulin-like GTPase involved in bacterial cell division (IC50s = 8.2 and 7 μg/ml, respectively). (-)-Viriditoxin inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 μM, respectively) . It is also toxic to mice (LD50 = 2.8 mg/kg, i.p.).
CAS:
1381782-08-6
Formula:
C34H30O14
Molecular Weight:
662.6
Purity:
0.98
SMILES:
OC1=CC(OC)=[C@]([C@]2=C(OC)C=C(O)C3=C2C=C(C[C@@H](CC(OC)=O)OC4=O)C4=C3O)C5=C1C(O)=C6C(C[C@@H](CC(OC)=O)OC6=O)=C5