TargetMol

SAR502250

Product Code:
 
TAR-T35560
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35560-5mg5mg£457.00
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Quantity:
TAR-T35560-50mg50mg£2,143.00
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Quantity:
TAR-T35560-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer?s disease (AD)[1][2].
CAS:
503860-57-9
Formula:
C19H18FN5O2
Molecular Weight:
367.38
Purity:
0.98
SMILES:
N/A

References

Griebel G, et, al. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer?s disease in rodents. Sci Rep. 2019 Dec 2;9(1):18045. Fukunaga K, et, al. 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7.