TargetMol

PF-06843195

Product Code:
 
TAR-T36308
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy[1].
CAS:
2067281-51-8
Formula:
C20H25F3N8O4
Molecular Weight:
498.46
Purity:
0.98
SMILES:
N/A

References

Hengmiao Cheng, et al. Structure-Based Drug Design and Synthesis of PI3K?-Selective Inhibitor (PF-06843195). J Med Chem. 2021 Jan 14;64(1):644-661.