TargetMol

Z-AEVD-FMK

Product Code:
 
TAR-T36331
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36331-10mg10mg£1,161.00
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Further Information

Bioactivity:
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
CAS:
1135688-47-9
Formula:
C28H39FN4O10
Molecular Weight:
610.636
Purity:
0.98
SMILES:
COC(=O)CC[C@H](NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

References

Park, S.J., Wu, C.H., Gordon, J.D., et al. Taxol induces caspase-10-dependent apoptosis. The Journal of Biological Chemisty 279(49), 51057-51067 (2004). Milhas, D., Cuvillier, O., Therville, N., et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. The Journal of Biological Chemisty 280(20), 19836-19842 (2005).